DNA damage and repair in atherosclerosis

Mahmoudi, M., Mercer, J.R. and Bennett, M. (2006) DNA damage and repair in atherosclerosis. Cardiovascular Research, 71(2), pp. 259-268. (doi: 10.1016/j.cardiores.2006.03.002)

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Abstract

There is increasing evidence that human atherosclerosis is associated with damage to the DNA of both circulating cells, and cells of the vessel wall. Reactive oxygen species are the most likely agents inducing DNA damage in atherosclerosis. DNA damage produces a variety of responses, including cell senescence, apoptosis and DNA repair. This review summarises the evidence for DNA damage in atherosclerosis, the cellular responses to damage and the mechanisms of signalling DNA damage.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Mercer, Dr John
Authors: Mahmoudi, M., Mercer, J.R., and Bennett, M.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences
Journal Name:Cardiovascular Research
Journal Abbr.:Cardiovasc Res
ISSN:0008-6363
ISSN (Online):1755-3245

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