Euglycemic clap insulin sensitivity and longitudinal systolic blood pressure: role of gender

Petrie, J. , Malik, M.O., Balkau, B., Perry, C.G., Højlund, K., Pataky, Z., Nolan, J., Ferrannini, E. and Natali, A. (2013) Euglycemic clap insulin sensitivity and longitudinal systolic blood pressure: role of gender. Hypertension, 62(2), pp. 404-409. (doi:10.1161/HYPERTENSIONAHA.111.00439)

Full text not currently available from Enlighten.

Abstract

Insulin resistance may be an independent risk factor for the development of hypertension, but change in blood pressure (BP) over time has not been adequately studied in healthy individuals fully characterised for insulin sensitivity. In the Relationship between Insulin Sensitivity and Cardiovascular disease (RISC) study, we measured insulin sensitivity (M/I) using the euglycemic clamp technique in 1,073 healthy European adults (587 women, 486 men) aged 30-60 years followed up three years later. Systolic BP (SBP) at baseline was higher in insulin resistant women (i.e. those in the low sex-specific M/I tertile) compared with those in the intermediate (P<0.001) or high tertiles (P=0.06) (mean ± SD: 117±13, 111± 12, 114±12 mmHg respectively). It did not differ across M/I tertiles in men. After adjustment for age, BMI, baseline systolic BP, and other covariates, low insulin sensitivity (M/I) predicted a longitudinal rise in systolic BP in women but not in men; M/I was not associated with change in diastolic BP. SBP rose over time in both genders and within all M/I tertiles (P<0.05) except in women with high insulin sensitivity. Therefore in women (but not in men), low insulin sensitivity was associated with higher systolic BP at three years and high insulin sensitivity was associated with a lower rise in systolic BP over time.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Perry, Dr Colin and Petrie, Professor John
Authors: Petrie, J., Malik, M.O., Balkau, B., Perry, C.G., Højlund, K., Pataky, Z., Nolan, J., Ferrannini, E., and Natali, A.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences
College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing
Journal Name:Hypertension
Publisher:American Heart Association
ISSN:0194-911X
ISSN (Online):1524-4563

University Staff: Request a correction | Enlighten Editors: Update this record