Gümüş, P., Buduneli, E., Bıyıkoğlu, B., Aksu, K., Saraç, F., Nile, C. , Lappin, D. and Buduneli, N. (2013) Gingival crevicular fluid, serum levels of receptor activator of nuclear factor-kappa B ligand, osteoprotegerin, interleukin-17 in rheumatoid arthritis and osteoporosis patients with periodontal disease. Journal of Periodontology, 84(11), pp. 1627-1637. (doi: 10.1902/jop.2013.120595)
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Abstract
Background: This study was performed to evaluate gingival crevicular fluid (GCF) and serum levels of soluble receptor activator of nuclear factor-kappa B ligand (sRANKL), interleukin (IL)-17A, IL-17E, IL-17F, IL-17A/F and osteoprotegerin (OPG) in rheumatoid arthritis (RA), osteoporosis (OPR) and systemically healthy (SH) women all with periodontal disease. Methods: Gingival crevicular fluid (GCF) and serum samples were obtained before any periodontal intervention from 17 RA, 19 OPR patients and 13 SH women with periodontitis. Full-mouth clinical periodontal measurements were recorded. sRANKL, OPG, IL-17 levels were determined by Enzyme-linked Immunosorbent Assay. Results: Clinical periodontal measurements were similar in the three study groups. Although the total amounts of GCF albumin, OPG, IL-17A and IL-17A/F, were similar in the study groups, there were statistically significant differences in GCF concentrations of sRANKL, OPG, IL-17A, IL-17E, IL-17F and IL-17A/F. The sRANKL/OPG ratio were significantly higher in the RA group than in the OPR and SH groups (p<0.05). Serum sRANKL, sRANKL/OPG and IL-17A/IL-17E ratios were significantly higher, while OPG concentrations were significantly lower in the RA group compared with other groups (p<0.05). Serum IL-17A concentrations were significantly higher in the RA and OPR groups than in the SH group (p<0.05). Conclusion: Increased inflammatory mediator levels in RA patients despite the long-term usage of various anti-inflammatory drugs suggest that these patients may have a propensity to overproduce these inflammatory mediators.
Item Type: | Articles |
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Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Lappin, Dr David and Nile, Dr Christopher |
Authors: | Gümüş, P., Buduneli, E., Bıyıkoğlu, B., Aksu, K., Saraç, F., Nile, C., Lappin, D., and Buduneli, N. |
Subjects: | R Medicine > RK Dentistry |
College/School: | College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing > Dental School |
Journal Name: | Journal of Periodontology |
ISSN: | 0022-3492 |
ISSN (Online): | 1943-3670 |
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