Elliott, R.M. and Blakqori, G. (2011) Molecular biology of orthobunyaviruses. In: Plyusnin, A. and Elliot, R.M. (eds.) Bunyaviridae: Molecular and Cellular Biology. Caister Academic Press: Norfolk, UK, pp. 1-39. ISBN 9781904455905
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Abstract
The <i>Orthobunyavirus</i> genus comprises over 170 named viruses, including the prototype of the <i>Bunyaviridae</i> family, Bunyamwera virus, as well medically significant viruses such as La Crosse and Oropouche viruses, and pathogens of veterinary importance like Akabane and Cache Valley viruses. In this chapter we review the molecular characteristics of orthobunyavirus genomes and encoded proteins, and details of the orthobunyavirus replication cycle. We describe how the development of reverse genetics has paved the way to understand interactions of orthobunyaviruses with the host cell, and in particular the evasion of the host innate immune response. Finally we review the differences in virus replication in vertebrate and invertebrate cells.
| Item Type: | Book Sections |
|---|---|
| Status: | Published |
| Glasgow Author(s) Enlighten ID: | Elliott, Professor Richard |
| Authors: | Elliott, R.M., and Blakqori, G. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Infection & Immunity |
| Publisher: | Caister Academic Press |
| ISBN: | 9781904455905 |
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