The influence of gender on the development of pulmonary arterial hypertension

Dempsie, Y. and Maclean, M. R. (2013) The influence of gender on the development of pulmonary arterial hypertension. Experimental Physiology, 98, pp. 1257-1261. (doi:10.1113/expphysiol.2012.069120)

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Publisher's URL: http://dx.doi.org/10.1113/expphysiol.2012.069120

Abstract

Pulmonary arterial hypertension (PAH) is a progressive disease in which increased pulmonary arterial pressure and remodelling eventually lead to right heart failure and death. Idiopathic and familial PAH occur far more frequently in women than in men. Historically, investigations into this gender bias have been impeded as female gender and oestrogens paradoxically protect against PAH in commonly used rodent models. However, recent descriptions of female gender specific murine models of PAH have led to an increased understanding of the role of oestrogens in disease development. Specifically, oestrogen metabolism has been highlighted as playing an important role in disease development and the oestrogen metabolising enzyme CYP1B1 may represent a novel therapeutic target. In addition, emerging evidence suggests that sex hormones may have direct effects on the right ventricle independent of hemodynamic effects. This review will discuss our current understanding of the role of sex hormones on the development of PAH.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:MacLean, Professor Margaret and Dempsie, Dr Yvonne
Authors: Dempsie, Y., and Maclean, M. R.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences
College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing
Journal Name:Experimental Physiology
Publisher:Wiley-Blackwell Publishing
ISSN:0958-0670
ISSN (Online):1469-445X
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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
573731Gender and the development of pulmonary arterial hypertension: regulation of genes from mouse to manMargaret MacleanBritish Heart Foundation (BHF)RG/11/7/28916RI CARDIOVASCULAR & MEDICAL SCIENCES
573733Gender and the development of pulmonary arterial hypertension: regulation of genes from mouse to manMargaret MacleanBritish Heart Foundation (BHF)RG/11/7/28916RI CARDIOVASCULAR & MEDICAL SCIENCES