Ramage, G. , Jose, A., Sherry, L. , Lappin, D. F., Jones, B. and Williams, C. (2013) Liposomal amphotericin B displays rapid dose-dependent activity against candida albicans biofilms. Antimicrobial Agents and Chemotherapy, 57(5), pp. 2369-2371. (doi: 10.1128/AAC.02344-12)
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Abstract
Biofilms formed by Candida albicans bloodstream isolates on catheters are an important clinical problem. Devising chemotherapeutic strategies to treat these in situ is an attractive option. We report here that liposomal amphotericin effectively kills C. albicans biofilms rapidly (12 h) and effectively (>90%) in a dose-dependent manner, whereas caspofungin displays an inverse concentration-dependent effect. This study has implications for considering the effective doses of antifungal agents used for catheter lock therapy.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Sherry, Dr Leighann and Jones, Dr Brian and Lappin, Dr David and Jose, Mr Anto and Ramage, Professor Gordon |
| Authors: | Ramage, G., Jose, A., Sherry, L., Lappin, D. F., Jones, B., and Williams, C. |
| College/School: | College of Medical Veterinary and Life Sciences College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing > Dental School |
| Journal Name: | Antimicrobial Agents and Chemotherapy |
| Journal Abbr.: | Antimicrob Agents Chemother |
| Publisher: | American Society for Microbiology |
| ISSN: | 0066-4804 |
| ISSN (Online): | 1098-6596 |
| Related URLs: |
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