Liposomal amphotericin B displays rapid dose-dependent activity against candida albicans biofilms

Ramage, G. , Jose, A., Sherry, L., Lappin, D. F., Jones, B. and Williams, C. (2013) Liposomal amphotericin B displays rapid dose-dependent activity against candida albicans biofilms. Antimicrobial Agents and Chemotherapy, 57(5), pp. 2369-2371. (doi:10.1128/AAC.02344-12)

Ramage, G. , Jose, A., Sherry, L., Lappin, D. F., Jones, B. and Williams, C. (2013) Liposomal amphotericin B displays rapid dose-dependent activity against candida albicans biofilms. Antimicrobial Agents and Chemotherapy, 57(5), pp. 2369-2371. (doi:10.1128/AAC.02344-12)

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Abstract

Biofilms formed by Candida albicans bloodstream isolates on catheters are an important clinical problem. Devising chemotherapeutic strategies to treat these in situ is an attractive option. We report here that liposomal amphotericin effectively kills C. albicans biofilms rapidly (12 h) and effectively (>90%) in a dose-dependent manner, whereas caspofungin displays an inverse concentration-dependent effect. This study has implications for considering the effective doses of antifungal agents used for catheter lock therapy.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Lappin, Dr David and Jose, Mr Anto and Ramage, Professor Gordon and Sherry, Dr Leighann and Jones, Dr Brian
Authors: Ramage, G., Jose, A., Sherry, L., Lappin, D. F., Jones, B., and Williams, C.
College/School:College of Medical Veterinary and Life Sciences
College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing > Dental School
Journal Name:Antimicrobial Agents and Chemotherapy
Journal Abbr.:Antimicrob Agents Chemother
Publisher:American Society for Microbiology
ISSN:0066-4804
ISSN (Online):1098-6596
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