Automatic synthesis of phosphopeptides by phosphorylation on the solid phase

de Bont, H.B.A., van Boom, J.H. and Liskamp, R.M.J. (1990) Automatic synthesis of phosphopeptides by phosphorylation on the solid phase. Tetrahedron Letters, 31(17), pp. 2497-2500. (doi:10.1016/S0040-4039(00)97399-4)

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Publisher's URL: http://dx.doi.org/10.1016/S0040-4039(00)97399-4

Abstract

An efficient automatic synthesis of phosphopeptides on the solid phase is described. Following completion of their synthesis on the solid support, peptides were phosphorylated using N,N-diisopropyl-bis(4-chlorobenzyl)phosphoramidite. After deprotection, pure phosphopeptides containing a phosphorylated serine or threonine were obtained in high yield.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Liskamp, Professor Robert
Authors: de Bont, H.B.A., van Boom, J.H., and Liskamp, R.M.J.
College/School:College of Science and Engineering > School of Chemistry
Journal Name:Tetrahedron Letters
ISSN:0040-4039

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