Peptides containing the novel methylphosphinamide transition-state isostere

Moree, W.J., van der Marel, G.A., van Boom, J.H. and Liskamp, R.M.J. (1993) Peptides containing the novel methylphosphinamide transition-state isostere. Tetrahedron, 49(47), pp. 11055-11064. (doi:10.1016/S0040-4020(01)80258-1)

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Publisher's URL: http://dx.doi.org/10.1016/S0040-4020(01)80258-1

Abstract

A convenient route towards the synthesis of peptides containing the methylphosphinamide moiety as a novel transition-state isostere of the amide bond hydrolysis is described. The key step being the coupling of a methylphosphinic chloride with an amino acid or peptide protected at the C-terminus. A proper choice of the amino protecting group appeared to be essential.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Liskamp, Professor Robert
Authors: Moree, W.J., van der Marel, G.A., van Boom, J.H., and Liskamp, R.M.J.
College/School:College of Science and Engineering > School of Chemistry
Journal Name:Tetrahedron
ISSN:0040-4020

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