Structure-based design of epitope mimetics

Moret, E.E., Liskamp, R.M.J. and Tollenaere, J.P. (1997) Structure-based design of epitope mimetics. Pharmacochemistry Library, 28, pp. 371-381. (doi:10.1016/S0165-7208(97)80079-7)

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Abstract

The challenge for medicinal chemistry to develop therapeutics for infections and chronic diseases is best met by aiding our immune response. Correct recognition of and adequate response to stimuli depends on B and T cell peptide epitopes. The effectiveness of designing new ligands mimicking bioactive peptides, but with enhanced metabolic stability, has become evident with the arrival of peptidomimetic research. To efficiently design peptidomimetics without affinity-loss, however, a detailed understanding of both the peptide's as well as the mimetics active site is of crucial importance.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Liskamp, Professor Robert
Authors: Moret, E.E., Liskamp, R.M.J., and Tollenaere, J.P.
College/School:College of Science and Engineering > School of Chemistry
Journal Name:Pharmacochemistry Library
ISSN:0165-7208
ISSN (Online):2212-0637

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