Moret, E.E., Liskamp, R.M.J. and Tollenaere, J.P. (1997) Structure-based design of epitope mimetics. Pharmacochemistry Library, 28, pp. 371-381. (doi: 10.1016/S0165-7208(97)80079-7)
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Abstract
The challenge for medicinal chemistry to develop therapeutics for infections and chronic diseases is best met by aiding our immune response. Correct recognition of and adequate response to stimuli depends on B and T cell peptide epitopes. The effectiveness of designing new ligands mimicking bioactive peptides, but with enhanced metabolic stability, has become evident with the arrival of peptidomimetic research. To efficiently design peptidomimetics without affinity-loss, however, a detailed understanding of both the peptide's as well as the mimetics active site is of crucial importance.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Liskamp, Professor Robert |
| Authors: | Moret, E.E., Liskamp, R.M.J., and Tollenaere, J.P. |
| College/School: | College of Science and Engineering > School of Chemistry |
| Journal Name: | Pharmacochemistry Library |
| ISSN: | 0165-7208 |
| ISSN (Online): | 2212-0637 |
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