Site-specific N-alkylation of peptides on the solid phase

Reichwein, J.F. and Liskamp, R.M.J. (1998) Site-specific N-alkylation of peptides on the solid phase. Tetrahedron Letters, 39(10), pp. 1243-1246. (doi: 10.1016/S0040-4039(97)10766-3)

Abstract

A convenient approach, featuring a Mitsunobu reaction, is described for the introduction of an alkyl group at a specific amide function of a peptide on the solid phase. This ‘site-specific alkylation’ procedure is illustrated with an N-ethyl scan of Leu-enkephalin.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Liskamp, Professor Robert
• Authors: Reichwein, J.F., and Liskamp, R.M.J.
• College/School: College of Science and Engineering > School of Chemistry
• Journal Name: Tetrahedron Letters
• ISSN: 0040-4039