Sequencing of peptoid peptidomimetics by Edman degradation

Boeijen, A. and Liskamp, R.M.J. (1998) Sequencing of peptoid peptidomimetics by Edman degradation. Tetrahedron Letters, 39(21), pp. 3589-3592. (doi: 10.1016/S0040-4039(98)00556-5)

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The direct identification of resin-bound peptoid peptidomimetics by sequencing is described. The N-terminus of the peptoid was treated with phenyl isothiocyanate, after which the N-terminal peptoid residue was cleaved from the resin as its thiohydantoin derivative. For deduction of the peptoid sequence, the HPLC retention times of the obtained thiohydantoins were compared to those of independently prepared reference thiohydantoins.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Liskamp, Professor Robert
Authors: Boeijen, A., and Liskamp, R.M.J.
College/School:College of Science and Engineering > School of Chemistry
Journal Name:Tetrahedron Letters
ISSN (Online):1873-3581

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