Increased stability of peptidesulfonamide peptidomimetics towards protease catalyzed degradation

de Bont, D.B.A., Sliedregt-Bol, K.M., Hofmeyer, L.J.F. and Liskamp, R.M.J. (1999) Increased stability of peptidesulfonamide peptidomimetics towards protease catalyzed degradation. Bioorganic and Medicinal Chemistry Letters, 7(6), pp. 1043-1047. (doi:10.1016/S0968-0896(99)00021-8)

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Abstract

Replacement of amide bonds in peptides by sulfonamide moieties resulted in peptidosulfonamides with an increased stability towards protease catalyzed degradation. In addition to protection of the protease cleavage site, it was found that introduction of a sulfonamide also influenced the stability of adjacent amide bonds.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Liskamp, Professor Robert
Authors: de Bont, D.B.A., Sliedregt-Bol, K.M., Hofmeyer, L.J.F., and Liskamp, R.M.J.
College/School:College of Science and Engineering > School of Chemistry
Journal Name:Bioorganic and Medicinal Chemistry Letters
ISSN:0960-894X
ISSN (Online):1464-3405

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