de Bont, D.B.A., Sliedregt-Bol, K.M., Hofmeyer, L.J.F. and Liskamp, R.M.J. (1999) Increased stability of peptidesulfonamide peptidomimetics towards protease catalyzed degradation. Bioorganic and Medicinal Chemistry Letters, 7(6), pp. 1043-1047. (doi: 10.1016/S0968-0896(99)00021-8)
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Abstract
Replacement of amide bonds in peptides by sulfonamide moieties resulted in peptidosulfonamides with an increased stability towards protease catalyzed degradation. In addition to protection of the protease cleavage site, it was found that introduction of a sulfonamide also influenced the stability of adjacent amide bonds.
Item Type: | Articles |
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Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Liskamp, Professor Robert |
Authors: | de Bont, D.B.A., Sliedregt-Bol, K.M., Hofmeyer, L.J.F., and Liskamp, R.M.J. |
College/School: | College of Science and Engineering > School of Chemistry |
Journal Name: | Bioorganic and Medicinal Chemistry Letters |
ISSN: | 0960-894X |
ISSN (Online): | 1464-3405 |
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