Rolling loop scan: an approach featuring ring-closing metathesis for generating libraries of peptides with molecular shapes mimicking bioactive conformations or local folding of peptides and proteins

Reichwein, J.F., Wels, B., Kruijtzer, J.A.W., Versluis, C. and Liskamp, R.M.J. (1999) Rolling loop scan: an approach featuring ring-closing metathesis for generating libraries of peptides with molecular shapes mimicking bioactive conformations or local folding of peptides and proteins. Angewandte Chemie (International Edition), 38(24), pp. 3684-3687. (doi:10.1002/(SICI)1521-3773(19991216)38:24<3684::AID-ANIE3684>3.0.CO;2-M)

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Abstract

Libraries of loop-containing peptides (such as the one shown schematically) can be prepared from bis-N-alkylated peptides by ring-closing metathesis. In a general solid-phase procedure the peptides are accessible by site-specific N-alkylation. Since the amino acid side chains are not involved in cyclization, they remain available for interaction with, for example, a receptor.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Liskamp, Professor Robert
Authors: Reichwein, J.F., Wels, B., Kruijtzer, J.A.W., Versluis, C., and Liskamp, R.M.J.
College/School:College of Science and Engineering > School of Chemistry
Journal Name:Angewandte Chemie (International Edition)
ISSN:1433-7851
ISSN (Online):1521-3773

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