Reichwein, J.F., Wels, B., Kruijtzer, J.A.W., Versluis, C. and Liskamp, R.M.J. (1999) Rolling loop scan: an approach featuring ring-closing metathesis for generating libraries of peptides with molecular shapes mimicking bioactive conformations or local folding of peptides and proteins. Angewandte Chemie (International Edition), 38(24), pp. 3684-3687. (doi: 10.1002/(SICI)1521-3773(19991216)38:24<3684::AID-ANIE3684>3.0.CO;2-M)
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Abstract
Libraries of loop-containing peptides (such as the one shown schematically) can be prepared from bis-N-alkylated peptides by ring-closing metathesis. In a general solid-phase procedure the peptides are accessible by site-specific N-alkylation. Since the amino acid side chains are not involved in cyclization, they remain available for interaction with, for example, a receptor.
Item Type: | Articles |
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Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Liskamp, Professor Robert |
Authors: | Reichwein, J.F., Wels, B., Kruijtzer, J.A.W., Versluis, C., and Liskamp, R.M.J. |
College/School: | College of Science and Engineering > School of Chemistry |
Journal Name: | Angewandte Chemie (International Edition) |
ISSN: | 1433-7851 |
ISSN (Online): | 1521-3773 |
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