Synthesis of cyclic peptides by ring-closing metathesis

Reichwein, J.F., Versluis, C. and Liskamp, R.M.J. (2000) Synthesis of cyclic peptides by ring-closing metathesis. Journal of Organic Chemistry, 65(19), pp. 6187-6195. (doi: 10.1021/jo000759t)

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The synthesis of a series of “amide to amide” cyclized peptides by ring-closing metathesis (RCM) as well as a convenient synthesis for the linear precursors is described. In addition, the influence of the length of the alkene substituents and the influence of the peptide sequence is investigated, leading to a set of general rules to obtain “amide to amide” cyclized peptides by RCM.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Liskamp, Professor Robert
Authors: Reichwein, J.F., Versluis, C., and Liskamp, R.M.J.
College/School:College of Science and Engineering > School of Chemistry
Journal Name:Journal of Organic Chemistry
ISSN (Online):1520-6904

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