Bio-inspired synthetic receptor molecules towards mimicry of vancomycin

Monnee, M.C.F., Brouwer, A.J., Verbeek, L.M., van Wageningen, A.M.A. and Liskamp, R.M.J. (2001) Bio-inspired synthetic receptor molecules towards mimicry of vancomycin. Bioorganic and Medicinal Chemistry Letters, 11(12), pp. 1521-1525. (doi:10.1016/S0960-894X(01)00237-2)

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Abstract

A 512-member library of bio-inspired synthetic receptor molecules was prepared featuring a triazacyclophane scaffold. The purpose of this scaffold was to orient three (identical) peptide ‘binding arms’ in order to mimic an antibiotic binding cavity as is present in the vancomycin antibiotics. The library was screened with d-Ala-d-Ala and d-Ala-d-Lac containing ligands, which are present in the cell wall precursors of pathogenic bacteria. Screening and validation led to identification of a synthetic receptor capable of binding these ligands.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Liskamp, Professor Robert
Authors: Monnee, M.C.F., Brouwer, A.J., Verbeek, L.M., van Wageningen, A.M.A., and Liskamp, R.M.J.
College/School:College of Science and Engineering > School of Chemistry
Journal Name:Bioorganic and Medicinal Chemistry Letters
ISSN:0960-0894X
ISSN (Online):1464-3405

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