Solid-phase synthesis of oligourea peptidomimetics employing the Fmoc protection strategy

Boeijen, A., van Ameijde, J. and Liskamp, R.M.J. (2001) Solid-phase synthesis of oligourea peptidomimetics employing the Fmoc protection strategy. Journal of Organic Chemistry, 66(25), pp. 8454-8462. (doi:10.1021/jo010656q)

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Abstract

A solid-phaseFmoc-basedsynthesis strategy is described for oligourea peptidomimetics as well as a convenient general synthesis approach for the preparation of the required building blocks 5a−j and 5k. These are suitable for use in peptide or robot synthesizers, which is illustrated by the synthesis of oligourea peptidomimetics of part of Leu-enkephalin (10) and a neurotensin derivative (17).

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Liskamp, Professor Robert
Authors: Boeijen, A., van Ameijde, J., and Liskamp, R.M.J.
College/School:College of Science and Engineering > School of Chemistry
Journal Name:Journal of Organic Chemistry
ISSN:0022-3263
ISSN (Online):1520-6904

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