Solid-phase synthesis of oligourea peptidomimetics employing the Fmoc protection strategy

Boeijen, A., van Ameijde, J. and Liskamp, R.M.J. (2001) Solid-phase synthesis of oligourea peptidomimetics employing the Fmoc protection strategy. Journal of Organic Chemistry, 66(25), pp. 8454-8462. (doi: 10.1021/jo010656q)

Abstract

A solid-phaseFmoc-basedsynthesis strategy is described for oligourea peptidomimetics as well as a convenient general synthesis approach for the preparation of the required building blocks 5a−j and 5k. These are suitable for use in peptide or robot synthesizers, which is illustrated by the synthesis of oligourea peptidomimetics of part of Leu-enkephalin (10) and a neurotensin derivative (17).

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Liskamp, Professor Robert
• Authors: Boeijen, A., van Ameijde, J., and Liskamp, R.M.J.
• College/School: College of Science and Engineering > School of Chemistry
• Journal Name: Journal of Organic Chemistry
• ISSN: 0022-3263
• ISSN (Online): 1520-6904