A convenient synthesis of azido peptides by post-assembly diazo transfer on the solid phase applicable to large peptides

Rijkers, D.T.S., van Vugt, H.H.R., Jacobs, H.J.F. and Liskamp, R.M.J. (2002) A convenient synthesis of azido peptides by post-assembly diazo transfer on the solid phase applicable to large peptides. Tetrahedron Letters, 43(20), pp. 3657-3660. (doi:10.1016/S0040-4039(02)00629-9)

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Abstract

An efficient method for the conversion of solid phase bound peptide amines into azides by a diazo transfer using triflyl azide in the presence of divalent copper ions is described. α-Azido acids and azido peptides—up to 30 amino acids in length—are obtained in good yields and high purities after cleavage from the solid support.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Liskamp, Professor Robert
Authors: Rijkers, D.T.S., van Vugt, H.H.R., Jacobs, H.J.F., and Liskamp, R.M.J.
College/School:College of Science and Engineering > School of Chemistry
Journal Name:Tetrahedron Letters
ISSN:0040-4039
ISSN (Online):1873-3581

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