Synthesis and cholera toxin binding properties of a lactose-2-aminothiazoline conjugate

Vrasidas, I., Kemmink, J., Liskamp, R.M.J. and Pieters, R. J. (2002) Synthesis and cholera toxin binding properties of a lactose-2-aminothiazoline conjugate. Organic Letters, 4(10), pp. 1807-1808. (doi:10.1021/ol025909w)

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Abstract

During the search for improved monovalent ligands for cholera toxin (CT), a new lactose-2-aminothiazoline conjugate was discovered. In a fluorescence binding assay the compound was found to be one of the strongest relatively simple CT ligands to date with a Kd of 23 μM.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Liskamp, Professor Robert
Authors: Vrasidas, I., Kemmink, J., Liskamp, R.M.J., and Pieters, R. J.
College/School:College of Science and Engineering > School of Chemistry
Journal Name:Organic Letters
ISSN:1523-7060
ISSN (Online):1523-7052

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