Synthesis of cyclic (α2β)-tripeptides as potential peptide turn mimetics

Wels, B., Kruijtzer, J.A.W. and Liskamp, R.M.J. (2002) Synthesis of cyclic (α2β)-tripeptides as potential peptide turn mimetics. Organic Letters, 4(13), pp. 2173-2176. (doi: 10.1021/ol025988b)

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The solid-supported synthesis followed by cyclization in solution of cyclic (α2β)-tripeptides, potential peptide β-turn mimetics, is described. The cyclization takes advantage of facilitating the rotation between trans- and cis-rotamers of two amide bonds. The method is amenable to combinatorial approaches as is illustrated by the synthesis of a small array of cyclic (α2β)-tripeptides.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Liskamp, Professor Robert
Authors: Wels, B., Kruijtzer, J.A.W., and Liskamp, R.M.J.
College/School:College of Science and Engineering > School of Chemistry
Journal Name:Organic Letters
ISSN (Online):1523-7052

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