Synthesis of cyclic (α2β)-tripeptides as potential peptide turn mimetics

Wels, B., Kruijtzer, J.A.W. and Liskamp, R.M.J. (2002) Synthesis of cyclic (α2β)-tripeptides as potential peptide turn mimetics. Organic Letters, 4(13), pp. 2173-2176. (doi: 10.1021/ol025988b)

Abstract

The solid-supported synthesis followed by cyclization in solution of cyclic (α2β)-tripeptides, potential peptide β-turn mimetics, is described. The cyclization takes advantage of facilitating the rotation between trans- and cis-rotamers of two amide bonds. The method is amenable to combinatorial approaches as is illustrated by the synthesis of a small array of cyclic (α2β)-tripeptides.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Liskamp, Professor Robert
• Authors: Wels, B., Kruijtzer, J.A.W., and Liskamp, R.M.J.
• College/School: College of Science and Engineering > School of Chemistry
• Journal Name: Organic Letters
• ISSN: 1523-7060
• ISSN (Online): 1523-7052