Synthesis of cyclic peptidosulfonamides as scaffolds for MC4 pharmacophoric groups

Wels, B., Kruijtzer, J.A.W., Garner, K.M., Adan, R.A.H. and Liskamp, R.M.J. (2005) Synthesis of cyclic peptidosulfonamides as scaffolds for MC4 pharmacophoric groups. Bioorganic and Medicinal Chemistry Letters, 15(2), pp. 287-290. (doi: 10.1016/j.bmcl.2004.10.082)

Abstract

The synthesis of potential β-turn mimetics based on cyclic sulfonamide peptoid/peptoid hybrids is described. These are readily synthesized using a solid phase protocol followed by cyclization in solution, and their suitability to combinatorial approaches is illustrated by the synthesis of a small but diversely functionalized library.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Liskamp, Professor Robert
• Authors: Wels, B., Kruijtzer, J.A.W., Garner, K.M., Adan, R.A.H., and Liskamp, R.M.J.
• College/School: College of Science and Engineering > School of Chemistry
• Journal Name: Bioorganic and Medicinal Chemistry Letters
• ISSN: 0960-894X
• ISSN (Online): 1464-3405