Highly efficient coupling of β-substituted aminoethane sulfonyl azides with thio acids, toward a new chemical ligation reaction

Merkx, R., Brouwer, A.J., Rijkers, D.T.S. and Liskamp, R.M.J. (2005) Highly efficient coupling of β-substituted aminoethane sulfonyl azides with thio acids, toward a new chemical ligation reaction. Organic Letters, 7(6), pp. 1125-1128. (doi:10.1021/ol0501119)

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Abstract

A highly efficient coupling of protected β-substituted aminoethane sulfonyl azides with thio acids is reported. In the case of peptide thio acids, this method encompasses a new chemoselective ligation method. Furthermore, the resulting α-amino acyl sulfonamides can be alkylated with suitable electrophiles to obtain densely functionalized sulfonamide scaffolds.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Liskamp, Professor Robert
Authors: Merkx, R., Brouwer, A.J., Rijkers, D.T.S., and Liskamp, R.M.J.
College/School:College of Science and Engineering > School of Chemistry
Journal Name:Organic Letters
ISSN:1523-7060
ISSN (Online):1523-7052

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