Highly efficient coupling of β-substituted aminoethane sulfonyl azides with thio acids, toward a new chemical ligation reaction

Merkx, R., Brouwer, A.J., Rijkers, D.T.S. and Liskamp, R.M.J. (2005) Highly efficient coupling of β-substituted aminoethane sulfonyl azides with thio acids, toward a new chemical ligation reaction. Organic Letters, 7(6), pp. 1125-1128. (doi: 10.1021/ol0501119)

Abstract

A highly efficient coupling of protected β-substituted aminoethane sulfonyl azides with thio acids is reported. In the case of peptide thio acids, this method encompasses a new chemoselective ligation method. Furthermore, the resulting α-amino acyl sulfonamides can be alkylated with suitable electrophiles to obtain densely functionalized sulfonamide scaffolds.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Liskamp, Professor Robert
• Authors: Merkx, R., Brouwer, A.J., Rijkers, D.T.S., and Liskamp, R.M.J.
• College/School: College of Science and Engineering > School of Chemistry
• Journal Name: Organic Letters
• ISSN: 1523-7060
• ISSN (Online): 1523-7052