Wels, B., Kruijtzer, J.A.W., Garner, K., Nijenhuis, W.A.J., Gispen, W.H., Adan, R.A.H. and Liskamp, R.M.J. (2005) Synthesis of a novel potent cyclic peptide MC4-ligand by ring-closing metathesis. Bioorganic and Medicinal Chemistry, 13(13), pp. 4221-4227. (doi: 10.1016/j.bmc.2005.04.027)
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Abstract
The synthesis of a novel potent cyclic peptide MC4-ligand by ring-closing metathesis (RCM) is described. Based on the Ac-Nle-Gly-Lys-d-Phe-Arg-Trp-Gly-NH2–MC4 ligand, Ac-Nle-Alg-Lys-d-Phe-Arg-Trp-Alg-NH2 was designed and synthesized followed by cyclization using RCM. Both compounds are high affinity and selective MC4-R-agonists. The cyclic RCM-peptide was more potent in a rat-grooming assay.
Item Type: | Articles |
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Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Liskamp, Professor Robert |
Authors: | Wels, B., Kruijtzer, J.A.W., Garner, K., Nijenhuis, W.A.J., Gispen, W.H., Adan, R.A.H., and Liskamp, R.M.J. |
College/School: | College of Science and Engineering > School of Chemistry |
Journal Name: | Bioorganic and Medicinal Chemistry |
ISSN: | 0968-0896 |
ISSN (Online): | 1464-3391 |
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