Alkene- and alkyne-bridged mimics of nisin as potential peptide-based antibiotics

Ghalit, N., Rijkers, D.T.S. and Liskamp, R.M.J. (2006) Alkene- and alkyne-bridged mimics of nisin as potential peptide-based antibiotics. Journal of Molecular Catalysis A: Chemical, 254(1-2), pp. 68-77. (doi:10.1016/j.molcata.2006.03.029)

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Abstract

Here we highlight our recent results of the application of ring-closing metathesis and ring-closing alkyne metathesis (RCAM) in biologically relevant biomolecules in order to introduce alkene- and/or alkyne-bridges as novel covalent constraints for stabilizing their bioactive conformation and increasing their metabolic stability.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Liskamp, Professor Robert
Authors: Ghalit, N., Rijkers, D.T.S., and Liskamp, R.M.J.
College/School:College of Science and Engineering > School of Chemistry
Journal Name:Journal of Molecular Catalysis A: Chemical
ISSN:1381-1169

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