Ghalit, N., Rijkers, D.T.S. and Liskamp, R.M.J. (2006) Alkene- and alkyne-bridged mimics of nisin as potential peptide-based antibiotics. Journal of Molecular Catalysis A: Chemical, 254(1-2), pp. 68-77. (doi: 10.1016/j.molcata.2006.03.029)
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Abstract
Here we highlight our recent results of the application of ring-closing metathesis and ring-closing alkyne metathesis (RCAM) in biologically relevant biomolecules in order to introduce alkene- and/or alkyne-bridges as novel covalent constraints for stabilizing their bioactive conformation and increasing their metabolic stability.
Item Type: | Articles |
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Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Liskamp, Professor Robert |
Authors: | Ghalit, N., Rijkers, D.T.S., and Liskamp, R.M.J. |
College/School: | College of Science and Engineering > School of Chemistry |
Journal Name: | Journal of Molecular Catalysis A: Chemical |
ISSN: | 1381-1169 |
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