A new chemical probe for the detection of the cancer-linked galectin-3

Ballell, L., van Scherpenzeel, M., Buchalova, K., Liskamp, R.M.J. and Pieters, R.J. (2006) A new chemical probe for the detection of the cancer-linked galectin-3. Organic and Biomolecular Chemistry, 4, pp. 4387-4394. (doi:10.1039/b611050a)

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Abstract

A chemical probe was developed for the detection of the emerging cancer marker galectin-3. The probe contains a benzophenone moiety which covalently attaches itself to the protein upon binding and irradiation. Introduction of a fluorescent label via ‘click’ chemistry allows the labelled proteins to be visualized in a gel. With the probe, selective visualization of galectin-3 in protein mixtures was shown and remarkably even in cell lysates.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Liskamp, Professor Robert
Authors: Ballell, L., van Scherpenzeel, M., Buchalova, K., Liskamp, R.M.J., and Pieters, R.J.
College/School:College of Science and Engineering > School of Chemistry
Journal Name:Organic and Biomolecular Chemistry
Publisher:Royal Society of Chemistry
ISSN:1477-0520

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