Detection of galectin-3 by novel peptidic photoprobes

van Scherpenzeel, M., van der Pot, M., Arnusch, C.J., Liskamp, R.M.J. and Pieters, R.J. (2006) Detection of galectin-3 by novel peptidic photoprobes. Bioorganic and Medicinal Chemistry Letters, 17(2), pp. 376-378. (doi:10.1016/j.bmcl.2006.10.043)

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Abstract

Photoprobes were prepared with specificity for binding, labeling, and visualizing galectin-3 in a mixture of proteins. The probes were derived from a galectin-3 binding 15-mer peptide sequence in which a benzophenone photolabel was incorporated at the N-terminus and in another case as a phenyl alanine replacement in the middle of the sequence. Detection of galectin-3 was possible in Escherichia coli lysates that were spiked with various amounts of galectin-3.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Liskamp, Professor Robert
Authors: van Scherpenzeel, M., van der Pot, M., Arnusch, C.J., Liskamp, R.M.J., and Pieters, R.J.
College/School:College of Science and Engineering > School of Chemistry
Journal Name:Bioorganic and Medicinal Chemistry Letters
ISSN:0960-894X

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