Solid-phase carbohydrate synthesis via on-bead protecting group chemistry

Branderhorst, H.M., Liskamp, R.M.J. and Pieters, R.J. (2007) Solid-phase carbohydrate synthesis via on-bead protecting group chemistry. Tetrahedron, 63(20), pp. 4290-4296. (doi:10.1016/j.tet.2007.03.051)

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Publisher's URL: http://dx.doi.org/10.1016/j.tet.2007.03.051

Abstract

Di- and tri-saccharides were synthesized on a solid phase. The procedure started with a non-protected sugar linked via either cysteine or glutamine to a polystyrene resin. Selective dimethoxytritylation chemistry and subsequent steps yielded a resin-bound acceptor that could be glycosylated to yield β1,6-linked disaccharides. Reiteration of the procedure produced the trisaccharide.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Liskamp, Professor Robert
Authors: Branderhorst, H.M., Liskamp, R.M.J., and Pieters, R.J.
College/School:College of Science and Engineering > School of Chemistry
Journal Name:Tetrahedron
Publisher:Elsevier
ISSN:0040-4020
ISSN (Online):1464-5416

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