Application of the 1,3-dipolar cycloaddition reaction in chemical biology: approaches toward multivalent carbohydrates and peptides and peptide-based polymers

Pieters, R.J., Rijkers, D.T.S. and Liskamp, R.M.J. (2007) Application of the 1,3-dipolar cycloaddition reaction in chemical biology: approaches toward multivalent carbohydrates and peptides and peptide-based polymers. QSAR & Combinatorial Science, 26(11-12), pp. 1181-1190. (doi:10.1002/qsar.200740075)

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Abstract

In this mini review we highlight our recent results and the related literature regarding the application of the Cu(I)-catalyzed 1,3-dipolar cycloaddition “click” reaction. The synthetic applications of the click reaction focus on multivalent carbohydrates and peptides and peptide-based polymers. Furthermore, a related reaction is described involving the coupling of thio acids and sulfonyl azides leading to the chemoselective formation of amides.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Liskamp, Professor Robert
Authors: Pieters, R.J., Rijkers, D.T.S., and Liskamp, R.M.J.
College/School:College of Science and Engineering > School of Chemistry
Journal Name:QSAR & Combinatorial Science
Publisher:Wiley - V C H Verlag GmbH & Co. KGaA
ISSN:1611-020X
ISSN (Online):1611-0218

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