Preparation ofNG-substitutedl-arginine analogues suitable for solid phase peptide synthesis

Martin, N.I. and Liskamp, R.M.J. (2008) Preparation ofNG-substitutedl-arginine analogues suitable for solid phase peptide synthesis. Journal of Organic Chemistry, 73(19), pp. 7849-7851. (doi:10.1021/jo801517f)

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Abstract

A high-yielding and concise preparation of NG-substituted l-arginine analogues, suitably protected for use in solid phase peptide synthesis, is reported. The synthesis of each analogue employed an activated thiourea intermediate that was converted under mild conditions to the desired l-arginine analogue (10 examples, each in near quantitative yield). Subsequent allyl group removal provided each analogue in a form ideally suited for use in solid phase peptide synthesis.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Liskamp, Professor Robert
Authors: Martin, N.I., and Liskamp, R.M.J.
College/School:College of Science and Engineering > School of Chemistry
Journal Name:Journal of Organic Chemistry
ISSN:0022-3263
ISSN (Online):1520-6904

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