Martin, N.I. and Liskamp, R.M.J. (2008) Preparation ofNG-substitutedl-arginine analogues suitable for solid phase peptide synthesis. Journal of Organic Chemistry, 73(19), pp. 7849-7851. (doi: 10.1021/jo801517f)
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Abstract
A high-yielding and concise preparation of NG-substituted l-arginine analogues, suitably protected for use in solid phase peptide synthesis, is reported. The synthesis of each analogue employed an activated thiourea intermediate that was converted under mild conditions to the desired l-arginine analogue (10 examples, each in near quantitative yield). Subsequent allyl group removal provided each analogue in a form ideally suited for use in solid phase peptide synthesis.
Item Type: | Articles |
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Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Liskamp, Professor Robert |
Authors: | Martin, N.I., and Liskamp, R.M.J. |
College/School: | College of Science and Engineering > School of Chemistry |
Journal Name: | Journal of Organic Chemistry |
ISSN: | 0022-3263 |
ISSN (Online): | 1520-6904 |
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