Arnusch, C.J., Bonvin, A.M.J.J., Verel, A.M., Jansen, W.T.M., Liskamp, R.M.J. , de Kruijff, B., Pieters, R.J. and Breukink, E. (2008) The vancomycin−nisin(1−12)hybrid restores activity against vancomycin resistant enterococci. Biochemistry, 47(48), pp. 12661-12663. (doi: 10.1021/bi801597b)
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Abstract
Lipid II is a crucial component in bacterial cell wall synthesis [Breukink, E., et al. (1999) Science 286, 2361−2364]. It is the target of a number of important antibiotics, which include vancomycin and nisin [Breukink, E., and de Kruijff, B. (2006) Nat. Rev. Drug Discovery 5, 321−332]. Here we show that a hybrid antibiotic that consists of vancomycin and nisin fragments is significantly more active than the separate fragments against vancomycin resistant entercocci (VRE). Three different hybrids were synthesized using click chemistry and compared. Optimal spacer lengths and connection points were predicted using computer modeling.
Item Type: | Articles |
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Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Liskamp, Professor Robert |
Authors: | Arnusch, C.J., Bonvin, A.M.J.J., Verel, A.M., Jansen, W.T.M., Liskamp, R.M.J., de Kruijff, B., Pieters, R.J., and Breukink, E. |
College/School: | College of Science and Engineering > School of Chemistry |
Journal Name: | Biochemistry |
ISSN: | 0006-2960 |
ISSN (Online): | 1520-4995 |
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