Versatile selective α-carboxylic acid esterification of N-protected amino acids and peptides by alcalase

Nuijens, T., Cusan, C., Kruijtzer, J.A.W., Rijkers, D.T.S., Liskamp, R.M.J. and Quaedflieg, P.J.L.M. (2009) Versatile selective α-carboxylic acid esterification of N-protected amino acids and peptides by alcalase. Synthesis, 2009(5), pp. 809-814. (doi: 10.1055/s-0028-1083362)

Abstract

Under continuous removal of water, the industrial protease Alcalase allows selective synthesis of α-carboxylic acid methyl, ethyl, benzyl, allyl, 2-(trimethylsilyl)ethyl, and tert-butyl esters of amino acids and peptides under mild conditions in very high yields. The purified yields range from 72% to 92%.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Liskamp, Professor Robert
• Authors: Nuijens, T., Cusan, C., Kruijtzer, J.A.W., Rijkers, D.T.S., Liskamp, R.M.J., and Quaedflieg, P.J.L.M.
• College/School: College of Science and Engineering > School of Chemistry
• Journal Name: Synthesis
• ISSN: 0039-7881