Potential scorpionate antibiotics: targeted hydrolysis of lipid II containing model membranes by vancomycin–TACzyme conjugates and modulation of their antibacterial activity by Zn-ions

Bauke Albada, H., Arnusch, C.J., Branderhorst, H.M., Verel, A.-M., Janssen, W.T.M., Breukink, E., de Kruijff, B., Pieters, R.J. and Liskamp, R.M.J. (2009) Potential scorpionate antibiotics: targeted hydrolysis of lipid II containing model membranes by vancomycin–TACzyme conjugates and modulation of their antibacterial activity by Zn-ions. Bioorganic and Medicinal Chemistry Letters, 19(14), pp. 3721-3724. (doi:10.1016/j.bmcl.2009.05.064)

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Abstract

The antibiotic vancomycin—that binds lipid II in the bacterial cell membrane—was conjugated to a mono- and tetravalent mimic of the tris-histidine catalytic triad of metalloenzymes. Targeted hydrolysis by the conjugate was observed using model membranes containing lipid II, and in vitro MIC-values of the targeted mimic constructs could be modulated by Zn-ions.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Liskamp, Professor Robert
Authors: Bauke Albada, H., Arnusch, C.J., Branderhorst, H.M., Verel, A.-M., Janssen, W.T.M., Breukink, E., de Kruijff, B., Pieters, R.J., and Liskamp, R.M.J.
College/School:College of Science and Engineering > School of Chemistry
Journal Name:Bioorganic and Medicinal Chemistry Letters
ISSN:0960-894X
ISSN (Online):1464-3405

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