Bauke Albada, H., Arnusch, C.J., Branderhorst, H.M., Verel, A.-M., Janssen, W.T.M., Breukink, E., de Kruijff, B., Pieters, R.J. and Liskamp, R.M.J. (2009) Potential scorpionate antibiotics: targeted hydrolysis of lipid II containing model membranes by vancomycin–TACzyme conjugates and modulation of their antibacterial activity by Zn-ions. Bioorganic and Medicinal Chemistry Letters, 19(14), pp. 3721-3724. (doi: 10.1016/j.bmcl.2009.05.064)
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Abstract
The antibiotic vancomycin—that binds lipid II in the bacterial cell membrane—was conjugated to a mono- and tetravalent mimic of the tris-histidine catalytic triad of metalloenzymes. Targeted hydrolysis by the conjugate was observed using model membranes containing lipid II, and in vitro MIC-values of the targeted mimic constructs could be modulated by Zn-ions.
Item Type: | Articles |
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Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Liskamp, Professor Robert |
Authors: | Bauke Albada, H., Arnusch, C.J., Branderhorst, H.M., Verel, A.-M., Janssen, W.T.M., Breukink, E., de Kruijff, B., Pieters, R.J., and Liskamp, R.M.J. |
College/School: | College of Science and Engineering > School of Chemistry |
Journal Name: | Bioorganic and Medicinal Chemistry Letters |
ISSN: | 0960-894X |
ISSN (Online): | 1464-3405 |
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