Synthesis and applications of biomedical and pharmaceutical polymers via click chemistry methodologies

van Dijk, M., Rijkers, D.T.S., Liskamp, R.M.J. , van Nostrum, C.F. and Hennink, W.E. (2009) Synthesis and applications of biomedical and pharmaceutical polymers via click chemistry methodologies. Bioconjugate Chemistry, 20(11), pp. 2001-2016. (doi:10.1021/bc900087a)

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Abstract

In this review, the synthesis and application of biomedical and pharmaceutical polymers synthesized via the copper(I)-catalyzed alkyne-azide cycloaddition, the thiol−ene reaction, or a combination of both click reactions are discussed. Since the introduction of both “click” methods, numerous articles have disclosed new approaches for the synthesis of polymers with different architectures, e.g., block and graft copolymers, dendrimers, and hydrogels, for pharmaceutical and biomedical applications. By describing selected examples, an overview is given of the possibilities and limitations that these two “click” methods may offer.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Liskamp, Professor Robert
Authors: van Dijk, M., Rijkers, D.T.S., Liskamp, R.M.J., van Nostrum, C.F., and Hennink, W.E.
College/School:College of Science and Engineering > School of Chemistry
Journal Name:Bioconjugate Chemistry
ISSN:1043-1802
ISSN (Online):1520-4812

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