Towards the synthesis of sulfonamide-based RNA mimetics

van Ameijde, J., Slot, T.K. and Liskamp, R.M.J. (2010) Towards the synthesis of sulfonamide-based RNA mimetics. Tetrahedron: Asymmetry, 21(4), pp. 469-475. (doi:10.1016/j.tetasy.2010.02.005)

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Abstract

The scalable, divergent synthesis of all four monomers required for the preparation of sulfonamide-based RNA mimetics is described. Such mimetics may combine excellent mimicry of the parent RNA with enhanced (bio)chemical robustness and convenient oligomerization. As a proof of principle, a dimer resulting from the monomers is described.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Liskamp, Professor Robert
Authors: van Ameijde, J., Slot, T.K., and Liskamp, R.M.J.
College/School:College of Science and Engineering > School of Chemistry
Journal Name:Tetrahedron: Asymmetry
ISSN:0957-4166
ISSN (Online):1362-511X

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