Triazacyclophane (TAC)-scaffolded histidine and aspartic acid residues as mimics of non-heme metalloenzyme active sites

Albada, H.B., Soulimani, F., Jacobs, H.J.F., Versluis, C., Weckhuysen, B.M. and Liskamp, R.M.J. (2012) Triazacyclophane (TAC)-scaffolded histidine and aspartic acid residues as mimics of non-heme metalloenzyme active sites. Organic and Biomolecular Chemistry, 10(5), pp. 1088-1092. (doi:10.1039/c1ob06806g)

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Abstract

We describe the synthesis and coordination behaviour to copper(II) of two close structural triazacyclophane-based mimics of two often encountered aspartic acid and histidine containing metalloenzyme active sites. Coordination of these mimics to copper(I) and their reaction with molecular oxygen leads to the formation of dimeric bis(μ-hydroxo) dicopper(II) complexes.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Liskamp, Professor Robert
Authors: Albada, H.B., Soulimani, F., Jacobs, H.J.F., Versluis, C., Weckhuysen, B.M., and Liskamp, R.M.J.
College/School:College of Science and Engineering > School of Chemistry
Journal Name:Organic and Biomolecular Chemistry
ISSN:1477-0520

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