Görmer, K., Bürger, M., Kruijtzer, J.A.W., Vetter, I., Vartak, N., Brunsveld, L., Bastiaens, P.I.H., Liskamp, R.M.J. , Triola, G. and Waldmann, H. (2012) Chemical-biological exploration of the limits of the ras de- and repalmitoylating machinery. ChemBioChem, 13(7), pp. 1017-1023. (doi: 10.1002/cbic.201200078)
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Abstract
A dynamic de-/repalmitoylation cycle determines localization and activity of H- and N-Ras. This combined cellular de- and repalmitoylation machinery has been shown to be substrate tolerant—it accepts variation of amino acid sequence, structure and configuration. Here, semisynthetic Ras-proteins in which the C-terminal amino acids are replaced by peptoid residues are used to reveal the first limitations of substrate recognition by the de- and repalmitoylating machinery.
Item Type: | Articles |
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Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Liskamp, Professor Robert |
Authors: | Görmer, K., Bürger, M., Kruijtzer, J.A.W., Vetter, I., Vartak, N., Brunsveld, L., Bastiaens, P.I.H., Liskamp, R.M.J., Triola, G., and Waldmann, H. |
College/School: | College of Science and Engineering > School of Chemistry |
Journal Name: | ChemBioChem |
Publisher: | Wiley |
ISSN: | 1439-4227 |
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