Chemical-biological exploration of the limits of the ras de- and repalmitoylating machinery

Görmer, K., Bürger, M., Kruijtzer, J.A.W., Vetter, I., Vartak, N., Brunsveld, L., Bastiaens, P.I.H., Liskamp, R.M.J. , Triola, G. and Waldmann, H. (2012) Chemical-biological exploration of the limits of the ras de- and repalmitoylating machinery. ChemBioChem, 13(7), pp. 1017-1023. (doi:10.1002/cbic.201200078)

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Abstract

A dynamic de-/repalmitoylation cycle determines localization and activity of H- and N-Ras. This combined cellular de- and repalmitoylation machinery has been shown to be substrate tolerant—it accepts variation of amino acid sequence, structure and configuration. Here, semisynthetic Ras-proteins in which the C-terminal amino acids are replaced by peptoid residues are used to reveal the first limitations of substrate recognition by the de- and repalmitoylating machinery.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Liskamp, Professor Robert
Authors: Görmer, K., Bürger, M., Kruijtzer, J.A.W., Vetter, I., Vartak, N., Brunsveld, L., Bastiaens, P.I.H., Liskamp, R.M.J., Triola, G., and Waldmann, H.
College/School:College of Science and Engineering > School of Chemistry
Journal Name:ChemBioChem
Publisher:Wiley
ISSN:1439-4227

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