Glucocorticoid-loaded core-cross-linked polymeric micelles with tailorable release kinetics for targeted therapy of rheumatoid arthritis

Crielaard, B.J. et al. (2012) Glucocorticoid-loaded core-cross-linked polymeric micelles with tailorable release kinetics for targeted therapy of rheumatoid arthritis. Angewandte Chemie (International Edition), 51(29), pp. 7254-7258. (doi:10.1002/anie.201202713)

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Abstract

Polymerizable and hydrolytically cleavable dexamethasone (DEX, red dot in picture) derivatives were covalently entrapped in core-cross-linked polymeric micelles that were prepared from a thermosensitive block copolymer (yellow and gray building block). By varying the oxidation degree of the thioether in the drug linker, the release rate of DEX could be controlled. The DEX-loaded micelles were used for efficient treatment of inflammatory arthritis in two animal models.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Liskamp, Professor Robert
Authors: Crielaard, B.J., Rijcken, C.J.F., Quan, L., van der Wal, S., Altintas, I., van der Pot, M., Kruijtzer, J.A.W., Liskamp, R.M.J., Schiffelers, R.M., van Nostrum, C.F., Hennink, W.E., Wang, D., Lammers, T., and Storm, G.
College/School:College of Science and Engineering > School of Chemistry
Journal Name:Angewandte Chemie (International Edition)
Publisher:Wiley - V C H Verlag GmbH & Co. KGaA
ISSN:1433-7851

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