Synthesis of cyclic peptides containing a thioester handle for native chemical ligation

van de Langemheen, H., Brouwer, A.J., Kemmink, J., Kruijtzer, J.A.W. and Liskamp, R.M.J. (2012) Synthesis of cyclic peptides containing a thioester handle for native chemical ligation. Journal of Organic Chemistry, 77(22), pp. 10058-10064. (doi:10.1021/jo3015566)

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Abstract

The synthesis of cyclic peptides containing a thioester handle using a sulfo-click linker is reported. These cyclic peptides can be coupled to N-terminal cysteine-containing constructs via native chemical ligation. A successful application of a cyclic peptide bearing a thioester handle in native chemical ligation is shown by a high yielding ligation.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Liskamp, Professor Robert
Authors: van de Langemheen, H., Brouwer, A.J., Kemmink, J., Kruijtzer, J.A.W., and Liskamp, R.M.J.
College/School:College of Science and Engineering > School of Chemistry
Journal Name:Journal of Organic Chemistry
Publisher:American Chemical Society
ISSN:0022-3263
ISSN (Online):1520-6904

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