Synthesis of cyclic peptides containing a thioester handle for native chemical ligation

van de Langemheen, H., Brouwer, A.J., Kemmink, J., Kruijtzer, J.A.W. and Liskamp, R.M.J. (2012) Synthesis of cyclic peptides containing a thioester handle for native chemical ligation. Journal of Organic Chemistry, 77(22), pp. 10058-10064. (doi: 10.1021/jo3015566)

Abstract

The synthesis of cyclic peptides containing a thioester handle using a sulfo-click linker is reported. These cyclic peptides can be coupled to N-terminal cysteine-containing constructs via native chemical ligation. A successful application of a cyclic peptide bearing a thioester handle in native chemical ligation is shown by a high yielding ligation.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Liskamp, Professor Robert
• Authors: van de Langemheen, H., Brouwer, A.J., Kemmink, J., Kruijtzer, J.A.W., and Liskamp, R.M.J.
• College/School: College of Science and Engineering > School of Chemistry
• Journal Name: Journal of Organic Chemistry
• Publisher: American Chemical Society
• ISSN: 0022-3263
• ISSN (Online): 1520-6904