Blood pressure response to patterns of weather fluctuations and effect on mortality

Aubini è re-Robb, L. et al. (2013) Blood pressure response to patterns of weather fluctuations and effect on mortality. Hypertension, 62(1), pp. 190-196. (doi:10.1161/HYPERTENSIONAHA.111.00686)

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Abstract

Very few studies have looked at longitudinal intraindividual blood pressure responses to weather conditions. There are no data to suggest that specific response to changes in weather will have an impact on survival. We analyzed >169 000 clinic visits of 16 010 Glasgow Blood Pressure Clinic patients with hypertension. Each clinic visit was mapped to the mean West of Scotland monthly weather (temperature, sunshine, rainfall) data. Percentage change in blood pressure was calculated between pairs of consecutive clinic visits, where the weather alternated between 2 extreme quartiles (Q1–Q4 or Q4–Q1) or remained in the same quartile (Qn–Qn) of each weather parameter. Subjects were also categorized into 2 groups depending on whether their blood pressure response in Q1–Q4 or Q4–Q1 were concordant or discordant to Qn–Qn. Generalized estimating equations and Cox proportional hazards model were used to model the effect on longitudinal blood pressure and mortality, respectively. Qn–Qn showed a mean 2% drop in blood pressure consistently, whereas Q4–Q1 showed a mean 2.1% and 1.6% rise in systolic and diastolic blood pressure, respectively. However, Q1–Q4 did not show significant changes in blood pressure. Temperature-sensitive subjects had significantly higher mortality (1.35 [95% confidence interval, 1.06–1.71]; P=0.01) and higher follow-up systolic blood pressure (1.85 [95% confidence interval, 0.24–3.46]; P=0.02) compared with temperature-nonsensitive subjects. Blood pressure response to temperature may be one of the underlying mechanisms that determine long-term blood pressure variability. Knowing a patient’s blood pressure response to weather can help reduce unnecessary antihypertensive treatment modification, which may in turn increase blood pressure variability and, thus, risk.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Hastie, Dr Claire and Padmanabhan, Professor Sandosh and Patel, Dr Rajan and Dominiczak, Professor Anna and Sloan, Mr William and Morrison, Dr David and Mccallum, Dr Linsay and Dawson, Professor Jesse and McInnes, Professor Gordon and Muir, Dr Scott and Walters, Professor Matthew
Authors: Aubini è re-Robb, L., Jeemon, P., Hastie, C.E., Patel, R.K., McCallum, L., Morrison, D., Walters, M., Dawson, J., Sloan, W., Muir, S., Dominiczak, A.F., McInnes, G.T., and Padmanabhan, S.
College/School:College of Medical Veterinary and Life Sciences > Institute of Health and Wellbeing > Public Health
College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences
College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing
Journal Name:Hypertension
Publisher:American Heart Association
ISSN:0194-911X
ISSN (Online):1524-4563

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