Everett, R.D., Boutell, C. and Hale, B.G. (2013) Interplay between viruses and host sumoylation pathways. Nature Reviews Microbiology, 11(6), pp. 400-411. (doi: 10.1038/nrmicro3015) (PMID:23624814)
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Abstract
Post-translational modification by members of the small ubiquitin-like modifier (SUMO) family of proteins is important for the regulation of many cellular proteins and pathways. As obligate parasites, viruses must engage with the host cell throughout their replication cycles, and it is therefore unsurprising that there are many examples of interplay between viral proteins and the host sumoylation system. This article reviews recent advances in this field, summarizing information on sumoylated viral proteins, the varied ways in which viruses engage with SUMO-related pathways, and the consequences of these interactions for viral replication and engagement with innate and intrinsic immunity.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Everett, Professor Roger and Boutell, Dr Chris and Hale, Dr Benjamin |
| Authors: | Everett, R.D., Boutell, C., and Hale, B.G. |
| Subjects: | Q Science > QR Microbiology > QR355 Virology |
| College/School: | College of Medical Veterinary and Life Sciences > School of Infection & Immunity College of Medical Veterinary and Life Sciences > School of Infection & Immunity > Centre for Virus Research |
| Journal Name: | Nature Reviews Microbiology |
| ISSN: | 1740-1526 |
| ISSN (Online): | 1740-1534 |
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