Cortical depth dependent functional responses in humans at 7T: improved specificity with 3D GRASE

De Martino, F., Zimmermann, J., Muckli, L. , Ugurbil, K., Yacoub, E. and Goebel, R. (2013) Cortical depth dependent functional responses in humans at 7T: improved specificity with 3D GRASE. PLoS ONE, 8(3), e60514. (doi: 10.1371/journal.pone.0060514) (PMID:23533682) (PMCID:PMC3606277)

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Abstract

Ultra high fields (7T and above) allow functional imaging with high contrast-to-noise ratios and improved spatial resolution. This, along with improved hardware and imaging techniques, allow investigating columnar and laminar functional responses. Using gradient-echo (GE) (T2* weighted) based sequences, layer specific responses have been recorded from human (and animal) primary visual areas. However, their increased sensitivity to large surface veins potentially clouds detecting and interpreting layer specific responses. Conversely, spin-echo (SE) (T2 weighted) sequences are less sensitive to large veins and have been used to map cortical columns in humans. T2 weighted 3D GRASE with inner volume selection provides high isotropic resolution over extended volumes, overcoming some of the many technical limitations of conventional 2D SE-EPI, whereby making layer specific investigations feasible. Further, the demonstration of columnar level specificity with 3D GRASE, despite contributions from both stimulated echoes and conventional T2 contrast, has made it an attractive alternative over 2D SE-EPI. Here, we assess the spatial specificity of cortical depth dependent 3D GRASE functional responses in human V1 and hMT by comparing it to GE responses. In doing so we demonstrate that 3D GRASE is less sensitive to contributions from large veins in superficial layers, while showing increased specificity (functional tuning) throughout the cortex compared to GE.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Muckli, Professor Lars
Authors: De Martino, F., Zimmermann, J., Muckli, L., Ugurbil, K., Yacoub, E., and Goebel, R.
College/School:College of Medical Veterinary and Life Sciences > Institute of Neuroscience and Psychology
Journal Name:PLoS ONE
Publisher:Public Library of Science
ISSN:1932-6203
Copyright Holders:Copyright © 2013 The Authors
First Published:First published in PLoS ONE 8(3):e60514
Publisher Policy:Reproduced under a Creative Commons License

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