Slowly and rapidly digestible starchy foods can elicit a similar glycemic response because of differential tissue glucose uptake in healthy men

Eelderink, C., Schepers, M., Preston, T. , Vonk, R.J., Oudhuis, L. and Priebe, M.G. (2012) Slowly and rapidly digestible starchy foods can elicit a similar glycemic response because of differential tissue glucose uptake in healthy men. American Journal of Clinical Nutrition, 96(5), pp. 1017-1024. (doi:10.3945/ajcn.112.041947)

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Abstract

<p>Background: Previously we observed that the consumption of pasta and bread resulted in a similar glycemic response, despite a slower intestinal influx rate of glucose from the pasta. Underlying mechanisms of this effect were not clear.</p> <p>Objective: The objective was to investigate the differences in glucose kinetics and hormonal response after consumption of products with slow and rapid in vivo starch digestibility but with a similar glycemic response.</p> <p>Design: Ten healthy male volunteers participated in a crossover study and consumed 13C-enriched wheat bread or pasta while receiving a primed-continuous D-[6,6-2H2]glucose infusion. The dual-isotope technique enabled calculation of the following glucose kinetics: rate of appearance of exogenous glucose (RaE), endogenous glucose production, and glucose clearance rate (GCR). In addition, postprandial plasma concentrations of glucose, insulin, glucagon, and glucose-dependent insulinotropic polypeptide (GIP) were analyzed.</p> <p>Results: GIP concentrations after pasta consumption were lower than after bread consumption and strongly correlated with the RaE (r = 0.82, P < 0.01). The insulin response was also lower after pasta consumption (P < 0.01). In accordance with the low insulin response, the GCR was lower after pasta consumption, which explained the high glycemic response despite a low RaE.</p> <p>Conclusions: Slower intestinal uptake of glucose from a starchy food product can result in lower postprandial insulin and GIP concentrations, but not necessarily in a lower glycemic response, because of a slower GCR. Even without being able to reduce postprandial glycemia, products with slowly digestible starch can have beneficial long-term effects. These types of starchy products cannot be identified by using the glycemic index and therefore another classification system may be necessary.</p>

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Preston, Professor Thomas
Authors: Eelderink, C., Schepers, M., Preston, T., Vonk, R.J., Oudhuis, L., and Priebe, M.G.
College/School:College of Science and Engineering > Scottish Universities Environmental Research Centre
Journal Name:American Journal of Clinical Nutrition
ISSN:0002-9165
ISSN (Online):1938-3207

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