Iodine status during pregnancy in India and related neonatal and infant outcomes

Lean, M.I.F.A., Lean, M.E.J. , Yajnik, C.S., Bhat, D., Joshi, S.M., Raut, D.A., Lubree, H.G. and Combet, E. (2013) Iodine status during pregnancy in India and related neonatal and infant outcomes. Public Health Nutrition, 17(6), pp. 1353-1362. (doi:10.1017/S1368980013001201) (PMID:23659491)

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Abstract

Objective: To document iodine status in Indian pregnancies, associations with maternal diet and demographics, and offspring developmental measures. Design: Longitudinal study following mothers through pregnancy and offspring up to 24 months. Setting: Rural health-care centre (Vadu) and urban antenatal clinic (Pune) in the Maharashtra region of India. Subjects: Pregnant mothers at 17 (n 132) and 34 weeks’ (n 151) gestation and their infants from birth to the age of 24 months. Results: Median urinary iodine concentration (UIC) was 203 and 211 μg/l at 17 and 34 weeks of pregnancy, respectively (range 26–800 μg/l). Using the UIC distribution adjusted for within-person variation, extreme UIC quartiles were compared for predictors and outcomes. There was no correlation between UIC at 17 and 34 weeks, but 24 % of those with UIC in the lowest quartile at 17 weeks had UIC in the same lowest quartile at 34 weeks. Maternal educational, socio-economic status and milk products consumption (frequency) were different between the lowest and highest quartile of UIC at 34 weeks. Selected offspring developmental outcomes differed between the lowest and highest UIC quartiles (abdominal circumference at 24 months, subscapular and triceps skinfolds at 12 and 24 months). However, UIC was only a weak predictor of subscapular skinfold at 12 months and of triceps skinfold at 24 months. Conclusions: Median UIC in this pregnant population suggested adequate dietary provision at both gestational stages studied. Occasional high results found in spot samples may indicate intermittent consumption of iodine-rich foods. Maternal UIC had limited influence on offspring developmental outcomes.

Item Type:Articles
Keywords:Iodine, nutrition, prevention, pregnancy, India, neonatal outcomes, infant outcomes
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Lean, Professor Michael and Combet Aspray, Dr Emilie
Authors: Lean, M.I.F.A., Lean, M.E.J., Yajnik, C.S., Bhat, D., Joshi, S.M., Raut, D.A., Lubree, H.G., and Combet, E.
College/School:College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing
Journal Name:Public Health Nutrition
Journal Abbr.:PHN
Publisher:Cambridge University Press
ISSN:1368-9800
ISSN (Online):1475-2727
Published Online:09 May 2013
Copyright Holders:Copyright © 2013 Cambridge University Press
First Published:First published in Public Health Nutrition 17(6):1353-1362
Publisher Policy:Reproduced in accordance with the copyright policy of the publisher

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