Evolution of equine influenza virus in vaccinated horses

Murcia, P.R. et al. (2013) Evolution of equine influenza virus in vaccinated horses. Journal of Virology, 87(8), pp. 4768-4771. (doi:10.1128/JVI.03379-12)

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Abstract

Influenza A viruses are characterized by their ability to evade host immunity, even in vaccinated individuals. To determine how prior immunity shapes viral diversity in vivo, we studied the intra- and interhost evolution of equine influenza virus in vaccinated horses. Although the level and structure of genetic diversity were similar to those in naïve horses, intrahost bottlenecks may be more stringent in vaccinated animals, and mutations shared among horses often fall close to putative antigenic sites.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Baillie, Professor George and Murcia, Dr Pablo
Authors: Murcia, P.R., Baillie, G.J., Stack, J.C., Jervis, C., Elton, D., Mumford, J.A., Daly, J., Kellam, P., Grenfell, B.T., Holmes, E.C., and Wood, J.L.N.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences
College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Journal of Virology
ISSN:0022-538X
ISSN (Online):1098-5514
Published Online:06 February 2013

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