Coxiella burnetii in humans, domestic ruminants, and ticks in rural Western Kenya

Knobel, D.L. et al. (2013) Coxiella burnetii in humans, domestic ruminants, and ticks in rural Western Kenya. American Journal of Tropical Medicine and Hygiene, 88(3), pp. 513-518. (doi:10.4269/ajtmh.12-0169)

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Publisher's URL: http://dx.doi.org/10.4269/ajtmh.12-0169

Abstract

We conducted serological surveys for Coxiella burnetii in archived sera from patients that visited a rural clinic in western Kenya from 2007 to 2008 and in cattle, sheep, and goats from the same area in 2009. We also conducted serological and polymerase chain reaction-based surveillance for the pathogen in 2009–2010, in human patients with acute lower respiratory illness, in ruminants following parturition, and in ticks collected from ruminants and domestic dogs. Antibodies against C. burnetii were detected in 30.9% (N = 246) of archived patient sera and in 28.3% (N = 463) of cattle, 32.0% (N = 378) of goats, and 18.2% (N = 159) of sheep surveyed. Four of 135 (3%) patients with acute lower respiratory illness showed seroconversion to C. burnetii. The pathogen was detected by polymerase chain reaction in specimens collected from three of six small ruminants that gave birth within the preceding 24 hours, and in five of 10 pools (50%) of Haemaphysalis leachi ticks collected from domestic dogs.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Cleaveland, Professor Sarah and Halliday, Dr Joanna and Knobel, Mr Darryn
Authors: Knobel, D.L., Maina, A.N., Cutler, S.J., Ogola, E., Feikin, D.R., Junghae, M., Halliday, J.E.B., Richards, A., Breiman, R.F., Cleaveland, S., and Njenga, M.K.
College/School:College of Medical Veterinary and Life Sciences > Institute of Biodiversity Animal Health and Comparative Medicine
Journal Name:American Journal of Tropical Medicine and Hygiene
Publisher:American Society of Tropical Medicine and Hygiene
ISSN:0002-9637
Copyright Holders:Copyright © 2013 American Society of Tropical Medicine and Hygiene
First Published:First published in American Journal of Tropical Medicine and Hygiene 88(3):513-518
Publisher Policy:Reproduced in accordance with the copyright policy of the publisher

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
500531An integrated epidemiological study of zoonotic pathogens in linked human and animal populations in rural KenyaSarah CleavelandWellcome Trust (WELLCOME)081828/B/06/ZRI BIODIVERSITY ANIMAL HEALTH & COMPMED