Cardio-metabolic risk factors and cortical thickness in a neurologically healthy male population: results from the psychological, social and biological determinants of ill health (pSoBid) study

Krishnadas, R. et al. (2013) Cardio-metabolic risk factors and cortical thickness in a neurologically healthy male population: results from the psychological, social and biological determinants of ill health (pSoBid) study. NeuroImage: Clinical, 2(2013), pp. 646-657. (doi:10.1016/j.nicl.2013.04.012)

Krishnadas, R. et al. (2013) Cardio-metabolic risk factors and cortical thickness in a neurologically healthy male population: results from the psychological, social and biological determinants of ill health (pSoBid) study. NeuroImage: Clinical, 2(2013), pp. 646-657. (doi:10.1016/j.nicl.2013.04.012)

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Abstract

<p>Introduction: Cardio-metabolic risk factors have been associated with poor physical and mental health. Epidemiological studies have shown peripheral risk markers to be associated with poor cognitive functioning in normal healthy population and in disease. The aim of the study was to explore the relationship between cardio-metabolic risk factors and cortical thickness in a neurologically healthy middle aged population-based sample.</p> <p>Methods: T1-weighted MRI was used to create models of the cortex for calculation of regional cortical thickness in 40 adult males (average age = 50.96 years), selected from the PSOBID study. The relationship between cardio-vascular risk markers and cortical thickness across the whole brain, were examined using the general linear models. The relationship with various covariates of interest was explored.</p> <p>Results: Lipid fractions with greater triglyceride content (TAG, VLDL and LDL) were associated with greater cortical thickness pertaining to a number of regions in the brain. Greater C reactive protein (CRP) and Intercellular adhesion molecule (ICAM-1) levels were associated with cortical thinning pertaining to perisylvian regions in the left hemisphere. Smoking status and education status were significant covariates in the model.</p> <p>Conclusions: This exploratory study adds to a small body of existing literature increasingly showing a relationship between cardio-metabolic risk markers and regional cortical thickness involving a number of regions in the brain in a neurologically normal middle aged sample. A focused investigation of factors determining the inter-individual variations in regional cortical thickness in the adult brain could provide further clarity in our understanding of the relationship between cardio-metabolic factors and cortical structures.</p>

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:McConnachie, Dr Alex and Batty, Mr David and Ford, Professor Ian and Tannahill, Dr Carol and Shiels, Professor Paul and Cavanagh, Professor Jonathan and Millar, Professor Keith and Velupillai, Dr Yoganathan and McLean, Dr Jennifer and Mclean, Dr John and Packard, Professor Chris and Sattar, Professor Naveed and Krishnadas, Dr Rajeev
Authors: Krishnadas, R., Mclean, J., Batty, D.J., Burns, H., Deans, K.A., Ford, I., McConnachie, A., McGinty, A., McLean, J.S., Millar, K., Sattar, N., Shiels, P., Tannahill, C., Velupillai, Y.N., Packard, C.J., and Cavanagh, J.
Subjects:R Medicine > R Medicine (General)
College/School:College of Medical Veterinary and Life Sciences > Institute of Health and Wellbeing > Robertson Centre
College of Medical Veterinary and Life Sciences > Institute of Health and Wellbeing > Mental Health and Wellbeing
College of Medical Veterinary and Life Sciences > Institute of Cancer Sciences
College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences
College of Medical Veterinary and Life Sciences > Institute of Health and Wellbeing > Public Health
College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing
Journal Name:NeuroImage: Clinical
Publisher:Elsevier
ISSN:2213-1582
ISSN (Online):2213-1582
Published Online:22 April 2013
Copyright Holders:Copyright © 2013 The Authors
First Published:First published in Neuroimage: Clinical 2(2013):646-657
Publisher Policy:Reproduced in accordance with the copyright policy of the publisher

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