Mulder, G.E., Kruijtzer, J.A.W. and Liskamp, R.M.J. (2012) A combinatorial approach toward smart libraries of discontinuous epitopes of HIV gp120 on a TAC synthetic scaffold. Chemical Communications, 48(80), p. 10007. (doi: 10.1039/c2cc35310e)
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Abstract
We describe rapid and convenient access to smart libraries of protein surface discontinuous epitope mimics. Up to three different cyclic peptides, representing discontinuous epitopes in HIV-gp120, were conjugated to a triazacyclophane scaffold molecule via CuAAC. In this way protein mimics for use as synthetic vaccines and beyond will become available.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Liskamp, Professor Robert |
| Authors: | Mulder, G.E., Kruijtzer, J.A.W., and Liskamp, R.M.J. |
| College/School: | College of Science and Engineering > School of Chemistry |
| Journal Name: | Chemical Communications |
| Journal Abbr.: | Chem. Comm. |
| Publisher: | Royal Society of Chemistry |
| ISSN: | 1359-7345 |
| ISSN (Online): | 1364-548X |
| Published Online: | 10 August 2012 |
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