A combinatorial approach toward smart libraries of discontinuous epitopes of HIV gp120 on a TAC synthetic scaffold

Mulder, G.E., Kruijtzer, J.A.W. and Liskamp, R.M.J. (2012) A combinatorial approach toward smart libraries of discontinuous epitopes of HIV gp120 on a TAC synthetic scaffold. Chemical Communications, 48(80), p. 10007. (doi:10.1039/c2cc35310e)

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Abstract

We describe rapid and convenient access to smart libraries of protein surface discontinuous epitope mimics. Up to three different cyclic peptides, representing discontinuous epitopes in HIV-gp120, were conjugated to a triazacyclophane scaffold molecule via CuAAC. In this way protein mimics for use as synthetic vaccines and beyond will become available.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Liskamp, Professor Robert
Authors: Mulder, G.E., Kruijtzer, J.A.W., and Liskamp, R.M.J.
College/School:College of Science and Engineering > School of Chemistry
Journal Name:Chemical Communications
Journal Abbr.:Chem. Comm.
Publisher:Royal Society of Chemistry
ISSN:1359-7345
ISSN (Online):1364-548X
Published Online:10 August 2012

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