Recent developments in human immunodeficiency virus-1 latency research

Chan, C.N., Dietrich, I., Hosie, M.J. and Willett, B.J. (2013) Recent developments in human immunodeficiency virus-1 latency research. Journal of General Virology, 94(5), pp. 917-932. (doi: 10.1099/vir.0.049296-0)

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Abstract

Almost 30 years after its initial discovery, infection with the human immunodeficiency virus-1 (HIV-1) remains incurable and the virus persists due to reservoirs of latently infected CD4+ memory T-cells and sanctuary sites within the infected individual where drug penetration is poor. Reactivating latent viruses has been a key strategy to completely eliminate the virus from the host, but many difficulties and unanswered questions remain. In this review, the latest developments in HIV-persistence and latency research are presented.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Hosie, Professor Margaret and Dietrich, Dr Isabelle and Willett, Professor Brian and Chan, Mr Chi
Authors: Chan, C.N., Dietrich, I., Hosie, M.J., and Willett, B.J.
College/School:College of Medical Veterinary and Life Sciences > School of Veterinary Medicine
College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Journal of General Virology
Publisher:Society for General Microbiology
ISSN:0022-1317
ISSN (Online):1465-2099
Published Online:30 January 2013

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