Exploiting inflammation for therapeutic gain in pancreatic cancer

Steele, C.W., Jamieson, N.B. , Evans, T.R.J. , McKay, C.J., Sansom, O.J. , Morton, J. and Carter, C.R. (2013) Exploiting inflammation for therapeutic gain in pancreatic cancer. British Journal of Cancer, 108(5), pp. 997-1003. (doi:10.1038/bjc.2013.24)

Steele, C.W., Jamieson, N.B. , Evans, T.R.J. , McKay, C.J., Sansom, O.J. , Morton, J. and Carter, C.R. (2013) Exploiting inflammation for therapeutic gain in pancreatic cancer. British Journal of Cancer, 108(5), pp. 997-1003. (doi:10.1038/bjc.2013.24)

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Abstract

Pancreatic ductal adenocarcinoma (PDAC) is an aggressive malignancy associated with <5% 5-year survival, in which standard chemotherapeutics have limited benefit. The disease is associated with significant intra- and peritumoral inflammation and failure of protective immunosurveillance. Indeed, inflammatory signals are implicated in both tumour initiation and tumour progression. The major pathways regulating PDAC-associated inflammation are now being explored. Activation of leukocytes, and upregulation of cytokine and chemokine signalling pathways, both have been shown to modulate PDAC progression. Therefore, targeting inflammatory pathways may be of benefit as part of a multi-target approach to PDAC therapy. This review explores the pathways known to modulate inflammation at different stages of tumour development, drawing conclusions on their potential as therapeutic targets in PDAC.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Jamieson, Dr Nigel and Steele, Dr Colin and Morton, Dr Jennifer and Carter, Mr Christopher and Evans, Professor Thomas and Sansom, Professor Owen
Authors: Steele, C.W., Jamieson, N.B., Evans, T.R.J., McKay, C.J., Sansom, O.J., Morton, J., and Carter, C.R.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cancer Sciences
Journal Name:British Journal of Cancer
Publisher:Nature Publishing Group
ISSN:0007-0920
ISSN (Online):1532-1827
Published Online:05 February 2013
Copyright Holders:Copyright © 2013 Cancer Research UK
First Published:First published in British Journal of Cancer 108(5):997-1003
Publisher Policy:Reproduced under a Creative Commons License

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