MYC-y mice: From tumour initiation to therapeutic targeting of endogenous MYC

Morton, J. and Sansom, O.J. (2013) MYC-y mice: From tumour initiation to therapeutic targeting of endogenous MYC. Molecular Oncology, 7(2), pp. 248-258. (doi:10.1016/j.molonc.2013.02.015)

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Abstract

MYC is one of the best-studied oncogenes in terms of mouse models of malignancy. MYC overexpression has been targeted to several tissues using transgenic constructs, and more recently as mouse models have evolved, conditional systems have been developed to allow the regulation of MYC expression or activity in vivo. The ability to target MYC expression to specific tissues and cell lineages, as well as the ability to regulate that expression, has made genetically engineered mouse models (GEMM) a valuable resource for studying the importance of MYC in the process of tumourigenesis. Here we review how these models have been used to address the role of MYC in tumour initiation and maintenance, how subtle changes in levels of MYC can influence tumourigenesis, and finally the ongoing efforts to target endogenous MYC genetically and with novel therapies.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Morton, Dr Jennifer and Sansom, Professor Owen
Authors: Morton, J., and Sansom, O.J.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cancer Sciences
Journal Name:Molecular Oncology
Publisher:Elsevier
ISSN:1574-7891
Published Online:07 March 2013

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