Modelling synergistic interactions between HER2, Sprouty2 and PTEN in driving prostate carcinogenesis

Ahmad, I. , Gao, M., Patel, R. and Leung, H.Y. (2013) Modelling synergistic interactions between HER2, Sprouty2 and PTEN in driving prostate carcinogenesis. Asian Journal of Andrology, 15(3), pp. 323-327. (doi:10.1038/aja.2013.40)

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Publisher's URL: http://dx.doi.org/10.1038/aja.2013.40

Abstract

Prostate cancer remains a major global health issue and a major cause of morbidity and mortality in men worldwide. Activation of androgen receptor and inactivation of the tumour suppressor gene phosphatase and tensin homologue (PTEN) represent two major events in prostate carcinogenesis. Using a range of clinical resources, in vitro and in vivo models, we explored potential complex interactions among receptor tyrosine kinases (such as HER2/3 and EGFR) and tumour suppressor genes, namely, Sprouty2 (SPRY2) and PTEN. The impacts on their downstream effectors (including PI3K and MAPK) to result in fine regulation of the signalling networks were also considered, which may represent important targets for developing treatment in the context of personalized medicine.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Ahmad, Dr Imran and Leung, Professor Hing and Patel, Dr Rachana and Gao, Miss Meiling
Authors: Ahmad, I., Gao, M., Patel, R., and Leung, H.Y.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cancer Sciences
Journal Name:Asian Journal of Andrology
ISSN:1008-682X
ISSN (Online):1745-7262
Published Online:15 April 2013

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